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Such therapies have long been desired but minimally explored because the many efforts to establish hepatic cell therapies using direct injection into the liver or injection via a vascular route, such as the portal vein into the liver, resulted in low efficiencies, typically under 20%, of mature parenchymal cells and under 5% for stem/progenitors, and with donor cells distributing also to ectopic sites such as the lungs (Ito et al., 2009)